{
 "protocol": {
  "RATE": 40,
  "N_ARM": 150,
  "ENTRY": [
   0,
   6,
   12
  ],
  "REPS": 2000,
  "P0": 0.15,
  "effects": {
   "null": 0.0,
   "effective": 1.1155618469818829
  }
 },
 "results": {
  "no time trend": {
   "null": {
    "separate": {
     "rejection": 0.0475,
     "controls_used": 150.0
    },
    "concurrent": {
     "rejection": 0.05275,
     "controls_used": 157.0
    },
    "pooled": {
     "rejection": 0.0475,
     "controls_used": 328.0
    },
    "adjusted": {
     "rejection": 0.054,
     "controls_used": 328.0
    }
   },
   "effective": {
    "separate": {
     "rejection": 0.984,
     "controls_used": 150.0
    },
    "concurrent": {
     "rejection": 0.985,
     "controls_used": 157.0
    },
    "pooled": {
     "rejection": 0.99825,
     "controls_used": 328.0
    },
    "adjusted": {
     "rejection": 0.98525,
     "controls_used": 328.0
    }
   }
  },
  "seasons (\u00b15 points)": {
   "null": {
    "separate": {
     "rejection": 0.04225,
     "controls_used": 150.0
    },
    "concurrent": {
     "rejection": 0.04775,
     "controls_used": 157.0
    },
    "pooled": {
     "rejection": 0.05025,
     "controls_used": 328.0
    },
    "adjusted": {
     "rejection": 0.04925,
     "controls_used": 328.0
    }
   },
   "effective": {
    "separate": {
     "rejection": 0.985,
     "controls_used": 150.0
    },
    "concurrent": {
     "rejection": 0.983,
     "controls_used": 157.0
    },
    "pooled": {
     "rejection": 0.99625,
     "controls_used": 328.0
    },
    "adjusted": {
     "rejection": 0.98475,
     "controls_used": 328.0
    }
   }
  },
  "seasons + drift": {
   "null": {
    "separate": {
     "rejection": 0.045,
     "controls_used": 150.0
    },
    "concurrent": {
     "rejection": 0.03425,
     "controls_used": 157.0
    },
    "pooled": {
     "rejection": 0.04925,
     "controls_used": 328.0
    },
    "adjusted": {
     "rejection": 0.03525,
     "controls_used": 328.0
    }
   },
   "effective": {
    "separate": {
     "rejection": 0.9905,
     "controls_used": 150.0
    },
    "concurrent": {
     "rejection": 0.991,
     "controls_used": 157.0
    },
    "pooled": {
     "rejection": 1.0,
     "controls_used": 328.0
    },
    "adjusted": {
     "rejection": 0.99175,
     "controls_used": 328.0
    }
   }
  },
  "seasons, placebo only": {
   "null": {
    "separate": {
     "rejection": 0.05225,
     "controls_used": 150.0
    },
    "concurrent": {
     "rejection": 0.05075,
     "controls_used": 157.0
    },
    "pooled": {
     "rejection": 0.05025,
     "controls_used": 328.0
    },
    "adjusted": {
     "rejection": 0.0515,
     "controls_used": 328.0
    }
   },
   "effective": {
    "separate": {
     "rejection": 0.97725,
     "controls_used": 150.0
    },
    "concurrent": {
     "rejection": 0.9795,
     "controls_used": 157.0
    },
    "pooled": {
     "rejection": 0.99575,
     "controls_used": 328.0
    },
    "adjusted": {
     "rejection": 0.9805,
     "controls_used": 328.0
    }
   }
  }
 },
 "platform_size": {
  "patients": 828,
  "placebo": 378,
  "months": 21,
  "separate_patients": 900,
  "separate_placebo": 450
 }
}